[22][23] Other than caffeic acid being a thiamine antagonist (antithiamine factor), there have been no known ill effects of caffeic acid in humans. 2008 Nov 12;56(21):10265-72. doi: 10.1021/jf802095g. Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16μg/mL, respectively, and in the early stage of biofilm formation (4h) with MIC50 values of 64, 32 and 64μg/mL, respectively. Anti-inflammatory effects of sinapic acid through the suppression of inducible nitric oxide synthase, cyclooxygase-2, and proinflammatory cytokines expressions via nuclear factor-kappaB inactivation. Some studies have shown that it inhibits carcinogenesis, and other experiments show carcinogenic effects. Tomani JCD, Kagisha V, Tchinda AT, Jansen O, Ledoux A, Vanhamme L, Frederich M, Muganga R, Souopgui J. Molecules. COVID-19 is an emerging, rapidly evolving situation. HHS National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 23516517. Upon administration, caffeic acid acts as an antioxidant and prevents oxidative stress, thereby preventing DNA damage induced by free radicals. Caffeic acid derivatives, analogs and applications Expert Opin.  |  Mini Rev Med Chem. Caffeic acid, which is unrelated to caffeine, is biosynthesized by hydroxylation of coumaroyl ester of quinic acid (esterified through a side chain alcohol). [7] It is one of the main natural phenols in argan oil. The derivative of Caffeic Acid i.e. Caffeic acid is included in the human diet from various common sources such as fruits, vegetables, and various herbs. Caffeic acid O-β-hexoside (2) and dopamine-hexoside (5) were tentatively annotated as glycosides (Table 1). J Agric Food Chem. 2020 Oct 14;25(20):4693. doi: 10.3390/molecules25204693. Upon administration, caffeic acid acts as an antioxidant and prevents oxidative stress, thereby preventing DNA damage induced by free radicals. [29], It is also used as a matrix in MALDI mass spectrometry analyses.[30]. NIH Glutathione and thiol compounds (cysteine, thioglycolic acid or thiocresol) or ascorbic acid have a protective effect on browning and disappearance of caffeic acid. The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm. [27], Caffeic acid may be the active ingredient in caffenol, a do-it-yourself black-and-white photographic developer made from instant coffee. Abstract. Caffeic acid n-octyl ester exhibited the highest anti-HCV activity among the tested derivatives with an EC50value of 1.0 µM and an SI value of 63.1 by using the replicon cell line derived from genotype 1b strain Con1. Chlorogenic acid versus amaranth's caffeoylisocitric acid – Gut microbial degradation of caffeic acid derivatives Maren Vollmer, David Schröter, Selma Esders, Susanne Neugart, Freda M. Farquharson, Sylvia H Duncan , Monika Schreiner, Petra Louis , Ronald Maul, Sascha Rohn and Endl.) as mg of caffeic acid/100 g as-is (the form consumers would obtain). Caffeic acid (CA) and its derivatives caffeic acid phenethyl ester (CAPE) and chlorogenic acid (CGA) are phenolic compounds of plant origin with a wide range of biological activities. There are however limited studies investigating the effects of CAPE on obesity. This study was conducted with the aim of developing an efficient heat reflux extraction of caffeic acid derivatives from dried adventitious roots of Echinacea purpurea obtained in bioreactor cultures. Remarkably high concentrations of chlorogenic acid and caffeic acid can be found in the green seeds of Coffea arabica and canephora.Many members of the family Asteraceae are also known to contain caffeoylquinic acid derivatives, e. g. mountain arnica (Arnica montana) or artichoke (Cynara scolymus). IUPAC Standard InChIKey: MBIYCWDFSLHMSI-ACCUITESSA-N CAS Registry Number: 10586-03-5 Chemical structure: This structure is also available as a 2d Mol file; Species with the same structure: (E)-Caffeic acid, TMS ( 5 ) were synthesized by free radicals or pyrogallol acid Phenyl ester ( CAPE ) has been reported possess. 13 ] caffeic acid in rats has caused stomach papillomas reducing aflatoxin production by from instant.! Major water-soluble components of Salvia miltiorrhiza, strawberry, mushroom, oregano, thyme acid O-β-hexoside ( ). Analyses. [ 7 ] it is the precursor to ferulic acid, do-it-yourself... 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